GW0742 activates miR‐17‐5p and inhibits TXNIPNLRP3‐mediated

Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO-instillation in mice References

GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, μM and 2 μM for human PPARδ,

gw0742 Administration of GW0742 30 min before and 30 min after a challenge with CAR caused a reduction in all the parameters of inflammation

gw0742 Biochemphysiol Actions GW0742 is a highly selective PPARδ agonist EC50 = 1 nM vs 1 μM and 2 μM for PPARα and PPARγ, respectively